Axonal response of mitochondria to demyelination and complex IV activity within demyelinated axons in experimental models of multiple sclerosis

Author:

Licht‐Mayer Simon1,Campbell Graham R.1,Mehta Arpan R.12,McGill Katie1,Symonds Alex1,Al‐Azki Sarah3,Pryce Gareth3,Zandee Stephanie4ORCID,Zhao Chao5,Kipp Markus6,Smith Kenneth J.7,Baker David3,Altmann Daniel8,Anderton Stephen M.4,Kap Yolanda S.9,Laman Jon D.910,'t Hart Bert A.91011,Rodriguez Moses12,Franklin Robin J. M.5,Chandran Siddharthan12,Lassmann Hans13ORCID,Trapp Bruce D.14,Mahad Don J.1

Affiliation:

1. Centre for Clinical Brain Sciences University of Edinburgh Edinburgh UK

2. UK Dementia Research Institute University of Edinburgh Edinburgh UK

3. Blizard Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London London UK

4. Centre for Inflammation Research University of Edinburgh Edinburgh UK

5. Wellcome Trust‐MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre University of Cambridge, Cambridge Biomedical Campus Cambridge UK

6. Institute of Anatomy Rostock University Medical Center Rostock Germany

7. Department of Neuroinflammation, The UCL Queen Square Institute of Neurology University College London London UK

8. Faculty of Medicine, Department of Medicine Hammersmith Campus London UK

9. Department of Immunobiology Biomedical Primate Research Centre Rijswijk The Netherlands

10. Department Pathology and Medical Biology and MS Center Noord Nederland (MSCNN) University Groningen, University Medical Center Groningen Groningen The Netherlands

11. Department Anatomy and Neuroscience Amsterdam University Medical Center (VUMC) Amsterdam Netherlands

12. Department of Neurology and Immunology Mayo College of Medicine and Science Rochester Minnesota USA

13. Department of Neuroimmunology, Center for Brain Research Medical University Vienna Vienna Austria

14. Department of Neuroscience Lerner Research Institute, Cleveland Clinic Cleveland Ohio USA

Funder

Multiple Sclerosis Society

National Multiple Sclerosis Society

Korea National Institute of Health

International Progressive MS Alliance

Publisher

Wiley

Subject

Physiology (medical),Neurology (clinical),Neurology,Histology,Pathology and Forensic Medicine

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