Neutrophils extracellular traps and ferroptosis in diabetic wounds

Author:

Huang Yumeng1,Ding Youjun12,Wang Beizhi3,Ji Qian4,Peng Chen4,Tan Qian156

Affiliation:

1. Department of Burns and Plastic Surgery Nanjing Drum Tower Hospital Clinical College of Jiangsu University Nanjing China

2. Department of Emergency Surgery The Fourth Affiliated Hospital of Jiangsu University (Zhenjiang Fourth People's Hospital) Zhenjiang China

3. Department of Burns and Plastic Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing China

4. Department of Oncology Affiliated Hospital of Jiangsu University Zhenjiang China

5. Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China

6. Department of Burns and Plastic Surgery Anqing Shihua Hospital of Nanjing Drum Tower Hospital Group Anqing China

Abstract

AbstractWound healing is an extremely complex process involving multiple levels of cells and tissues. It is mainly completed through four stages: haemostasis, inflammation, proliferation, and remodelling. When any one of these stages is impaired, it may lead to delayed healing or even transformation into chronic refractory wounds. Diabetes is a kind of common metabolic disease that affects approximately 500 million people worldwide, 25% of whom develop skin ulcers that break down repeatedly and are difficult to heal, making it a growing public health problem. Neutrophils extracellular traps and ferroptosis are new types of programmed cell death identified in recent years and have been found to interact with diabetic wounds. In this paper, the normal wound healing and interfering factors of the diabetic refractory wound were outlined. The mechanism of two kinds of programmed cell death was also described, and the interaction mechanism between different types of programmed cell death and diabetic refractory wounds was discussed.

Publisher

Wiley

Subject

Dermatology,Surgery

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