Affiliation:
1. Division of Abdominal Organ Transplantation and Hepatobiliary Surgery, Department of Surgery, Keck School of Medicine University of Southern California Los Angeles California USA
Abstract
AbstractBackgroundCombined heart‐liver transplantation (CHLT) is a promising technique to address end stage organ failure in patients with concomitant heart failure and chronic liver disease. While most experience with CHLT has involved adult patients, the expanding population of children born with univentricular congenital heart disease who underwent the Fontan procedure and develop Fontan‐associated liver disease (FALD) has emerged as a growing indication for pediatric CHLT.MethodsCurrently, CHLT is performed at a select subset of experienced transplant centers, especially in the pediatric population.ResultsWhile technically demanding, CHLT may offer survival benefit when compared to heart transplant alone with decreased rejection of both synchronous allografts and equivalent outcomes with respect to waitlist time and post‐operative complications. Limitations in the technique can be attributed to need for an appropriate multidisciplinary care center, challenges with donor organ availability and allocation, and the complexity associated with patient selection and peri‐operative management.ConclusionIn this review, we summarize the history of CHLT, discuss patient selection, and highlight key facets of peri‐operative care in the pediatric population.
Funder
California Institute for Regenerative Medicine
National Cancer Institute
Subject
Transplantation,Pediatrics, Perinatology and Child Health
Reference42 articles.
1. RubinD.Calm after the storm.Texas Monthly. Published online April 1991. Accessed February 13 2023.https://www.texasmonthly.com/news‐politics/stormie‐jones‐ordeal‐after‐historic‐transplant/
2. Pediatric heart‐liver transplant outcomes in the United States: A 25‐year National Cohort Study
3. CASE REPORT OF COMBINED PEDIATRIC HEART-LUNG-LIVER TRANSPLANTATION
4. NHS Blood and Transplant.NHS Blood and Transplant Organ Donation and Transplantation clinical website.odt.nhs.uk
5. Eurotransplant.Statistics Report Library.https://statistics.eurotransplant.org