Treatment and mortality risk of older adults with non‐small cell cancer in Taiwan: A population‐based cohort study

Author:

Wang Chun‐Chieh12,Chiu Shao‐Wen3,Wu Shang‐Jung4,Pan Lung‐Kwang5,Yen Yung‐Feng678,Lai Yun‐Ju891011ORCID,Chen Chu‐Chieh8

Affiliation:

1. Division of Chest Medicine, Department of Internal Medicine Puli Branch of Taichung Veterans General Hospital Nantou Taiwan

2. Department of Eldercare Central Taiwan University of Science and Technology Taichung Taiwan

3. Healthcare Technology Business Division, Healthcare Department International Integrated Systems Taipei Taiwan

4. Department of Nursing Puli Branch of Taichung Veterans General Hospital Nantou Taiwan

5. Department of Medical Imaging and Radiological Science Central Taiwan University of Science and Technology Taichung Taiwan

6. Section of Infectious Diseases, Taipei City Hospital, Taipei City Government Taipei Taiwan

7. Institute of Hospital and Health Care Administration National Yang‐Ming University Taipei Taiwan

8. Department of Health Care Management National Taipei University of Nursing and Health Sciences Taipei Taiwan

9. School of Medicine National Yang‐Ming University Taipei Taiwan

10. Department of Exercise Health Science National Taiwan University of Sport Taichung Taiwan

11. Division of Endocrinology and Metabolism, Department of Internal Medicine Puli Branch of Taichung Veterans General Hospital Nantou Taiwan

Abstract

AbstractBackgroundOlder patients tend to have decreased physical functions and more comorbidities than younger patients. At present, the best management for very elderly patients with lung cancer is not known. In this study, we aimed to investigate treatment and mortality risk of older adults with non‐small cell cancer (NSCLC) in Taiwan.MethodsThis study analyzed data from the Taiwan Cancer Registry database. Patients aged ≥80 years with newly diagnosed NSCLC between 2010 and 2017 were included. Treatment options were categorized as curative, palliative, and no treatment. Patients were followed up until death or December 31, 2020. Univariable and multivariable Cox proportional hazards models were used to estimate mortality risk, and Kaplan–Meier survival curves were drawn.ResultsA total of 11 941 patients, aged ≥80 years, with newly diagnosed NSCLC between 2010 and 2017 were identified from the Taiwan Cancer Registry and followed up until 2020. The mean age was 84.4 ± 3.7 years old, and 7468 (62.54%) were men. The Kaplan–Meier survival curves showed significant differences across the three treatment options (log‐rank p < 0.001). Results from multivariate Cox regression demonstrated that patients on palliative treatment (adjusted HR: 0.52, 95% CI: 0.48–0.56, p < 0.001) and curative treatment (adjusted HR: 0.45, 95% CI: 0.42–0.48, p < 0.001) had a significantly lower mortality risk than those with no treatment. The subgroup analyses stratified by cancer stages also showed consistent findings.ConclusionElderly patients with NSCLC had significantly decreased mortality risk when receiving curative or palliative treatment compared with those without treatment. In the future, further studies are warranted to investigate complications and quality of life of elderly patients with NSCLC during palliative or curative treatment.

Publisher

Wiley

Subject

Pulmonary and Respiratory Medicine,Oncology,General Medicine

Reference34 articles.

1. GLOBOCAN 2020 Report on Global Cancer Burden: Challenges and Opportunities for Surgical Oncologists

2. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

3. Welfare MoHa.The cause of death in Taiwan in 2021.2021Available from:https://dep.mohw.gov.tw/DOS/lp-5069-113-xCat-y110.html

4. Health Promotion Administration. Ministry of Health and Welfare T.Cancer Registry Annual Report 2019.2019Available from:https://twcr.tw/wp-content/uploads/2022/02/CA16_LF108.pdf

5. Lung Cancer in Elderly Patients: An Analysis of the Surveillance, Epidemiology, and End Results Database

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