Screening forROS1gene rearrangements in non-small-cell lung cancers using immunohistochemistry with FISH confirmation is an effective method to identify this rare target

Author:

Selinger Christina I1,Li Bob T234,Pavlakis Nick24,Links Matthew5,Gill Anthony J46,Lee Adrian2,Clarke Stephen24,Tran Thang N1,Lum Trina1,Yip Po Y78910,Horvath Lisa4711,Yu Bing412,Kohonen-Corish Maija R J7813,O'Toole Sandra A147,Cooper Wendy A148

Affiliation:

1. Tissue Pathology and Diagnostic Oncology; Royal Prince Alfred Hospital; Camperdown NSW Australia

2. Department of Medical Oncology; Royal North Shore Hospital; St Leonards NSW Australia

3. Thoracic Oncology Service; Memorial Sloan Kettering Cancer Center; New York USA

4. Sydney Medical School; University of Sydney; Camperdown NSW Australia

5. Department of Medical Oncology; St George Hospital; Kogarah NSW Australia

6. Cancer Diagnosis and Pathology Group; Kolling Institute of Medical Research, Royal North Shore Hospital; St Leonards NSW Australia

7. The Kinghorn Cancer Centre; Garvan Institute of Medical Research; Darlinghurst NSW Australia

8. School of Medicine; University of Western Sydney; Sydney NSW Australia

9. Chris O'Brien Lifehouse; Camperdown NSW Australia

10. Macarthur Cancer Therapy Centre; Campbelltown Hospital; Camperdown NSW Australia

11. Medical Oncology; Royal Prince Alfred Hospital; Camperdown NSW Australia

12. Department of Medical Genomics; Royal Prince Alfred Hospital; Camperdown NSW Australia

13. St Vincent's Clinical School; University of New South Wales; Darlinghurst NSW Australia

Funder

CINSW

Sydney Breast Cancer Foundation

National Health and Medical Research Council

Tag family foundation

NIH/NCI Cancer Center Support

Publisher

Wiley

Subject

General Medicine,Histology,Pathology and Forensic Medicine

Reference48 articles.

1. ROS1 as a ‘druggable’ receptor tyrosine kinase: lessons learned from inhibiting the ALK pathway;Ou;Expert Rev. Anticancer Ther.,2012

2. Cellular sequences related to three new onc genes of avian sarcoma virus (fps, yes, and ros) and their expression in normal and transformed cells;Shibuya;J. Virol.,1982

3. Genetic structure and transforming sequence of avian sarcoma virus UR2;Wang;J. Virol.,1982

4. Some biological properties of two new avian sarcoma viruses;Balduzzi;J. Virol.,1981

5. Matrix-independent activation of phosphatidylinositol 3-kinase, Stat3, and cyclin A-associated Cdk2 Is essential for anchorage-independent growth of v-Ros-transformed chicken embryo fibroblasts;Uttamsingh;J. Biol. Chem.,2003

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