Fatal hepatic necrosis after nivolumab as a bridge to liver transplant for HCC: Are checkpoint inhibitors safe for the pretransplant patient?

Author:

Nordness Mina F.1ORCID,Hamel Stephanie2,Godfrey Caroline M.1,Shi Chanjuan3,Johnson Douglas B.4,Goff Laura W.4,O’Dell Heather1,Perri Roman E.5,Alexopoulos Sophoclis P.1

Affiliation:

1. Section of Surgical Sciences Department of Surgery Division of Hepatobiliary Surgery & Liver Transplantation Vanderbilt University Medical Center Nashville Tennessee

2. Department of Pharmaceutical Services Vanderbilt University Medical Center Nashville Tennessee

3. Department of Pathology Vanderbilt University Medical Center, Microbiology, Microbiology Nashville Tennessee

4. Department of Medicine Division of Hematology Oncology Vanderbilt University Medical Center Nashville Tennessee

5. Department of Medicine Division of Gastroenterology, Hepatology and Nutrition Vanderbilt University Medical Center Nashville Tennessee

Publisher

Wiley

Subject

Pharmacology (medical),Transplantation,Immunology and Allergy

Reference20 articles.

1. FDA grants accelerated approval to nivolumab for HCC previously treated with sorafenib.https://www.fda.gov/drugs/resources-information-approved-drugs/fda-grants-accelerated-approval-nivolumab-hcc-previously-treated-sorafenib. Accessed June 17 2019.

2. Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

3. Cancer immunotherapy using checkpoint blockade

4. Immune‐related adverse events with immune checkpoint blockade: a comprehensive review;Michot JM;Eur J Cancer,1990

5. Immune Checkpoint Inhibitor Toxicity in 2018

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