Pharmacological or transcriptional inhibition of both HDAC1 and 2 leads to cell cycle blockage and apoptosis via p21Waf1/Cip1 and p19INK4d upregulation in hepatocellular carcinoma

Author:

Zhou Hengyu12,Cai Ying13,Liu Dina1,Li Menghui14,Sha Yu1,Zhang Wenlu1,Wang Kai5,Gong Jianping4,Tang Ni1,Huang Ailong16,Xia Jie1ORCID

Affiliation:

1. Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education); Department of Infectious Diseases; The Second Affiliated Hospital; Institute for Viral Hepatitis; Chongqing Medical University; Chongqing China

2. Department of Intensive Care Medicine; The Second Affiliated Hospital of Chongqing Medical University; Chongqing China

3. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases; Zhejiang University; Hangzhou China

4. Department of Liver; The Second Affiliated Hospital; Chongqing Medical University; Chongqing China

5. Department of Pathogenic Biology; College of Basic Medical Sciences; Chongqing Medical University; Chongqing China

6. College of Nursing; Chongqing Medical University; Chongqing China

Funder

National Natural Science Foundation of China

Chongqing basic and frontier research project

Chongqing Medical University

Publisher

Wiley

Subject

Cell Biology,General Medicine

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