1. School of Life Sciences, Queen's Medical Centre; University of Nottingham; Nottingham NG7 2UH UK
2. Neuroscience and Psychiatry Unit; University of Manchester, Stopford Building; Oxford Road Manchester M13 9PT UK
3. Centre for Evidence Based Medicine, Nuffield Department of Primary Care Health Sciences; Radcliffe Observatory Quarter; Woodstock Road Oxford OX2 6GG UK