Amino acid divergence in the ligand‐binding pocket of Vibrio LuxR/HapR proteins determines the efficacy of thiophenesulfonamide inhibitors
Author:
Affiliation:
1. Department of Biology Indiana University Bloomington Indiana USA
2. Department of Chemistry Indiana University Bloomington Indiana USA
Funder
Indiana Clinical and Translational Sciences Institute
National Institutes of Health
Publisher
Wiley
Subject
Molecular Biology,Microbiology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1111/mmi.14804
Reference65 articles.
1. Quorum Sensing Gene Regulation by LuxR/HapR Master Regulators in Vibrios
2. The master quorum‐sensing regulators LuxR/HapR directly interact with the alpha subunit of RNA polymerase to drive transcription activation in Vibrio harveyi and Vibrio cholerae
3. Structure-Activity Relationship of Cinnamaldehyde Analogs as Inhibitors of AI-2 Based Quorum Sensing and Their Effect on Virulence of Vibrio spp
4. Cinnamaldehyde and cinnamaldehyde derivatives reduce virulence in Vibrio spp. by decreasing the DNA-binding activity of the quorum sensing response regulator LuxR
5. OpaR and RpoS are positive regulators of a virulence factor PrtA in Vibrio parahaemolyticus
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