Significant frequency of MSH2/MSH6 abnormality in ovarian endometrioid carcinoma supports histotype-specific Lynch syndrome screening in ovarian carcinomas-Reference-Cited by-同舟云学术

Significant frequency of MSH2/MSH6 abnormality in ovarian endometrioid carcinoma supports histotype-specific Lynch syndrome screening in ovarian carcinomas

Published:2016-02-26 Issue:2 Volume:69 Page:288-297
ISSN:0309-0167
Container-title:Histopathology
language:en
Short-container-title:Histopathology

Author:

Rambau Peter F¹²,Duggan Máire A²,Ghatage Prafull³,Warfa Khadija⁴,Steed Helen⁵,Perrier Renee⁶,Kelemen Linda E⁷⁸,Köbel Martin²

Affiliation:

1. Department of Pathology; Catholic University of Health and Allied Sciences-Bugando; Mwanza Tanzania

2. Department of Pathology and Laboratory Medicine; Calgary Laboratory Services/Alberta Health Services and University of Calgary; Calgary AB Canada

3. Department of Gynecological Oncology; Tom Baker Cancer Centre; University of Calgary; Calgary AB Canada

4. Department of Obstetrics and Gynaecology; Aga Khan University Hospital; Nairobi Kenya

5. Department of Obstetrics and Gynecology; University of Alberta; Edmonton AB Canada

6. Department of Medical Genetics; University of Calgary; Calgary AB Canada

7. Department of Public Health Sciences; College of Medicine; Charleston SC USA

8. Hollings Cancer Center; Medical University of South Carolina; Charleston SC USA

Funder

Canadian Institutes of Health Research

Publisher

Wiley

Subject

General Medicine,Histology,Pathology and Forensic Medicine

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/his.12934/fullpdf

Reference34 articles.

1. Comparison of clinical schemas and morphologic features in predicting Lynch syndrome in mutation-positive patients with endometrial cancer encountered in the context of familial gastrointestinal cancer registries;Ryan;Cancer,2012

2. Lynch syndrome screening should be considered for all patients with newly diagnosed endometrial cancer;Mills;Am. J. Surg. Pathol.,2014

3. Reflex immunohistochemistry and microsatellite instability testing of colorectal tumors for Lynch syndrome among US cancer programs and follow-up of abnormal results;Beamer;J. Clin. Oncol.,2012

4. Performance characteristics of screening strategies for Lynch syndrome in unselected women with newly diagnosed endometrial cancer who have undergone universal germline mutation testing;Ferguson;Cancer,2014

5. Immunohistochemical staining of hMLH1 and hMSH2 reflects microsatellite instability status in ovarian carcinoma;Rosen;Mod. Pathol.,2006

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