Affiliation:
1. School of Biology and Biological Engineering South China University of Technology Guangzhou China
Abstract
Liquid–liquid phase separation (LLPS) has been recognized as a universal biological phenomenon. It plays an important role in life activities. LLPS is induced by weak interactions between intrinsically disordered regions or low complex domains. Nucleic acids are widely present in cells, and shown to be closely related to LLPS. Their structure and electronegativity provide the excellent platforms for the formation of phase‐separated condensates. In this review, we summarize the interconnected regulation between nucleic acids and LLPS demonstrated in in vivo and in vitro studies. Beside homogeneous and single‐phase condensates, complicated and multicompartment LLPS induced by nucleic acids is discussed as well. Recent advances about nucleic‐acid‐induced LLPS as a new pathogenic mechanism and drug design direction are highlighted, especially virus‐mediated disease treatment and prevention.
Funder
National Basic Research Program of China
Natural Science Foundation of Guangdong Province
National Natural Science Foundation of China
Subject
Cell Biology,Molecular Biology,Biochemistry
Cited by
1 articles.
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