Deferasirox reduces oxidative DNA damage in bone marrow cells from myelodysplastic patients and improves their differentiation capacity

Author:

Jiménez‐Solas Tamara12ORCID,López‐Cadenas Félix12,Aires‐Mejía Irene12,Caballero‐Berrocal Juan Carlos12ORCID,Ortega Rebeca2,Redondo Alba María12,Sánchez‐Guijo Fermín12,Muntión Sandra12,García‐Martín Luís12,Albarrán Beatriz3,Alonso José María3,Del Cañizo Consuelo2,Hernández‐Hernández Ángel24ORCID,Díez‐Campelo María12ORCID

Affiliation:

1. Servicio de Hematología Hospital Universitario de Salamanca Salamanca Spain

2. Instituto de Investigación Biomédica de Salamanca (IBSAL) Salamanca Spain

3. Servicio de Hematología Complejo Asistencial Universitario de Palencia Palencia Spain

4. Departamento de Bioquímica y Biología Molecular Universidad de Salamanca Salamanca Spain

Funder

Fundación Ramón Areces

Novartis

Ministerio de Economía y Competitividad

Publisher

Wiley

Subject

Hematology

Reference51 articles.

1. Evidence‐ and consensus‐based practice guidelines for the therapy of primary myelodysplastic syndromes. A statement from the Italian Society of Hematology;Alessandrino E.P.;Haematologica,2002

2. Deferasirox for transfusion-dependent patients with myelodysplastic syndromes: safety, efficacy, and beyond (GIMEMA MDS0306 Trial)

3. Safety and efficacy, including event‐free survival, of deferasirox versus placebo in iron‐overloaded patients with low‐ and int‐1‐risk myelodysplastic syndromes (MDS): outcomes from the randomized, Double‐Blind Telesto Study;Angelucci E.;Blood,2018

4. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia

5. Reactive oxygen species in oncogenic transformation;Behrend L.;Molecular Mechanisms of Signalling,2003

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