Semi‐mechanistic modelling platform to assess cardiac contractility and haemodynamics in preclinical cardiovascular safety profiling of new molecular entities-Reference-Cited by-同舟云学术

Semi‐mechanistic modelling platform to assess cardiac contractility and haemodynamics in preclinical cardiovascular safety profiling of new molecular entities

Published:2020-06-18 Issue:15 Volume:177 Page:3568-3590
ISSN:0007-1188
Container-title:British Journal of Pharmacology
language:en
Short-container-title:Br J Pharmacol

Author:

Venkatasubramanian Raja¹,Collins Teresa A.²,Lesko Lawrence J.¹,Mettetal Jerome T.³,Trame Mirjam N.¹^ORCID

Affiliation:

1. Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy University of Florida Orlando Florida USA

2. Clinical Pharmacology and Safety Sciences R&D, AstraZeneca Cambridge UK

3. Early TDE Discovery R&D, AstraZeneca Waltham Massachusetts USA

Funder

AstraZeneca

Publisher

Wiley

Subject

Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bph.15079

Reference53 articles.

1. QA interval as an indirect measure of cardiac contractility in the conscious telemeterised rat: Model optimisation and evaluation

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