Effect of 5′‐adenosine monophosphate‐activated protein kinase agonists on insulin and glucose dynamics in experimentally induced insulin dysregulation in horses

Author:

Pinnell Erin F.12ORCID,Hostnik Laura D.1,Watts Mauria R.1,Timko Kathryn J.1ORCID,Thriffiley Allison A.1,Stover Mercedes R.1,Koenig Lauren E.1,Gorman Olivia M.1,Toribio Ramiro E.1ORCID,Burns Teresa A.1ORCID

Affiliation:

1. Department of Veterinary Clinical Sciences The Ohio State University College of Veterinary Medicine Columbus Ohio USA

2. Department of Veterinary Clinical Sciences Washington State University College of Veterinary Medicine Pullman Washington USA

Abstract

AbstractBackground5′‐adenosine monophosphate‐activated protein kinase (AMPK) agonists, particularly resveratrol (RES), have not been extensively evaluated for their effect on insulin dysregulation (ID) in horses.ObjectivesEvaluate the effects of treatment with RES (10 mg/kg PO q12h), metformin (MET; 30 mg/kg PO q12h), and aspirin (ASP; 20 mg/kg PO q24h) on experimentally induced ID.AnimalsThirty‐three healthy, adult, light‐breed horses.MethodsUnblinded, placebo‐controlled, experimental trial evaluating effects of AMPK agonists (RES, MET, and ASP) on experimentally induced ID. Horses were randomly assigned to a treatment group (RES, MET/ASP, RES/ASP, RES/MET/ASP, or placebo [CON]) after induction of ID with dexamethasone (0.08 mg/kg PO q24h for 7 days). Frequently sampled insulin‐modified IV glucose tolerance tests (FSIGTT) and oral sugar tests (OST) were performed at baseline, 7 days after ID, and ID plus 7 days of treatment. Minimal model and OST variables were compared between (1‐way ANOVA) and within (1‐way ANOVA for repeated measures) groups over time to determine effects of treatment on ID.ResultsAdministration of dexamethasone for 14 days resulted in significantly altered insulin and glucose dynamics (SI, DI, basal [glucose], and [insulin]) and produced clinical signs of laminitis in 5 out of 33 (15%) of horses included in the study. Combination therapy with RES, MET, and ASP did not significantly improve insulin and glucose dynamics in horses with experimentally induced ID.Conclusions and Clinical ImportanceMetabolic testing before glucocorticoid administration should be considered in horses with clinical signs of metabolic syndrome.

Funder

GJCRF

Publisher

Wiley

Subject

General Veterinary

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