Affiliation:
1. Clinical Laboratory Fujita Health University Hospital Toyoake Aichi Japan
2. Department of Cardiology Fujita Health University Toyoake Aichi Japan
3. Department of Cardiology School of Medicine and Menzies Health Queensland Griffith University G40 Griffith Health Centre Southport QLD Australia
4. Department of Joint Research Laboratory of Clinical Medicine Fujita Health University Toyoake Aichi Japan
Abstract
AbstractIntroductionCoronary computed tomography angiography (CCTA) is known to have a high negative predictive value (NPV) in identifying coronary artery disease (CAD). This study aimed to examine whether resting echocardiographic parameters could exclude significant CAD on CCTA.MethodsWe recruited 142 patients who had undergone both CCTA and echocardiography within a 3‐month window. Based on the CCTA findings, patients were divided into two groups: Group A (non‐significant CAD, defined as all coronary segments having <50% stenosis) and Group B (significant CAD). Resting echocardiographic parameters were compared between the two groups to identify predictors of non‐significant CAD on CCTA.ResultsA total 92 patients (mean age, 68 ± 13 years; males, 62%) were eligible for this study; 50 in Group A and 42 in Group B. Among the various echo parameters, left atrial volume index (LAVI) and left ventricular (LV) global longitudinal strain (GLS) were significantly lower in Group A (23.5 ± 7.6 vs. 33.6 ± 7.4 mL/m2, p < .001; −20.2 ± 1.8% vs. −16.8 ± 2.0%, p < .001, respectively). Analysis of the receiver operating characteristic curve revealed that the cutoff value to exclude significant CAD on CCTA was 29.0 mL/m2 for LAVI (NPV 80.8%) and −18.1% for GLS (NPV 80.7%). The NPV increased to 95.0% when these parameters were combined (LAVI < 29.0 mL/m2 and GLS < −18.1%).ConclusionThe combination of resting LAVI and GLS was clinically useful in excluding significant CAD via CCTA.
Subject
Cardiology and Cardiovascular Medicine,Radiology, Nuclear Medicine and imaging