Risk factors for uveitis in a Finnish sarcoid population

Author:

Joukainen Elli1ORCID,Antonen Jaakko2,Leinonen Sanna13ORCID

Affiliation:

1. Faculty of Medicine and Health Technology Tampere University Tampere Finland

2. Department of Internal Medicine Tampere University Hospital Tampere Finland

3. Tays Eye Centre Tampere University Hospital Tampere Finland

Abstract

AbstractPurposeTo evaluate possible risk factors for uveitis among Finnish sarcoidosis patients.MethodsPatient charts of patients with sarcoidosis, with (n = 97) or without (n = 255) uveitis, and with a comprehensive eye examination from January 2014 to January 2021 at Tays Eye Centre, Tampere University Hospital, Finland were studied.ResultsSarcoidosis patients with uveitis had higher rate of lymphocytopenia (43% vs. 29%, p = 0.041) and lower serum lysozyme levels (2.0 mg/L vs. 2.3 mg/L, p = 0.049; 95% CI, −0.692 to −0.002). Lysozyme level or lymphocytopenia did not have a statistically significant effect on the probability of uveitis in a binary logistic regression analysis. No other differences in the potential risk factors with p‐values ≤0.05 were found, including bilateral hilar lymphadenopathy, serum angiotensin‐converting enzyme (ACE) levels, sex, age and history of smoking.ConclusionLymphocytopenia and lower serum lysozyme levels present as possible risk factors for uveitis among patients with sarcoidosis. Systematic measurement of lymphocyte and lysozyme levels in sarcoidosis is needed to further understand their role as potential risk factors.

Funder

Pirkanmaan Rahasto

Publisher

Wiley

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