Affiliation:
1. Pediatric Department Azienda Sanitaria Universitaria Friuli Centrale Udine Italy
2. Allergy Unit Meyer Children's Hospital IRCCS Florence Italy
3. Department of Health Sciences University of Florence Florence Italy
4. Allergy Unit Hospital Regional Universitario de Málaga‐ARADyAL Málaga Spain
Abstract
AbstractDiagnosing Drug Hypersensitivity Reactions (DHRs) could be a complicated process especially in children, since allergic‐like manifestation at this age is more often the expression of concomitant infections rather than a actual DHRs. In vivo tests are usually suggested as a first step; however, prick and intradermal tests could be painful and have shown different sensitivity and specificity among published studies. In some cases, in vivo tests such as Drug Provocation test (DPT) could be even contraindicated. Therefore, the need for in vitro testing is compelling, to add useful information along the diagnostic pathway and to limit the need of DPT. In this review, we analyze the different types of in vitro tests, focusing on those used more widely such as specific IgE and on those that are still for research settings, such as basophil activation test and lymphocyte transformation test, but that have shown some useful diagnostic potential.
Subject
Immunology,Immunology and Allergy,Pediatrics, Perinatology and Child Health
Cited by
5 articles.
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