PEPDar: A randomized prospective noninferiority study of ritonavir-boosted darunavir for HIV post-exposure prophylaxis

Author:

Fätkenheuer G12,Jessen H3,Stoehr A4,Jung N1,Jessen AB3,Kümmerle T1,Berger M5,Bogner JR6,Spinner CD7,Stephan C8,Degen O9,Vogelmann R10,Spornraft-Ragaller P11,Schnaitmann E12,Jensen B13,Ulmer A14,Kittner JM15,Härter G16,Malfertheiner P17,Rockstroh J18,Knecht G19,Scholten S20,Harrer T21,Kern WV22,Salzberger B23,Schürmann D24,Ranneberg B25

Affiliation:

1. Department I of Internal Medicine; University Hospital of Cologne; Cologne Germany

2. German Centre for Infection Research, partner site Bonn-Cologne; Cologne Germany

3. Praxis Jessen2 + Kollegen; Berlin Germany

4. ifi - Institute for Interdisciplinary Medicine; Study Centre St. Georg; Hamburg Germany

5. Immunology Outpatient Clinic; Vivantes Auguste Viktoria Hospital; Berlin Germany

6. Section Infectcious Diseases, Med IV; University Hospital of Munich; Munich Germany

7. Department of Medicine II; University Hospital Klinikum rechts der Isar; Munich Germany

8. Department of Medicine; Center for Internal Medicine; J. W. Goethe-University Frankfurt; Frankfurt am Main Germany

9. Outpatient Infectious Diseases Unit; University Center Hamburg Eppendorf; Hamburg Germany

10. Department of Internal Medicine; Medical Clinic II; Ruprecht-Karls-University Heidelberg; Mannheim Germany

11. University Hospital Karl Gustav Carus; Dresden Germany

12. Infectomed; Stuttgart Germany

13. Department of Gastroenterology, Hepatology and Infectiology; University Hospital Düsseldorf; Düsseldorf Germany

14. Group Practice Ulmer/Frietsch/Müller/Roll; Stuttgart Germany

15. Medical Clinic and Outpatient Clinic I; University Hospital Mainz; Mainz Germany

16. Clinic for Internal Medizin III; Ulm University Medical Center; Ulm Germany

17. Clinic for Gastroenterology, Hepatology and Infectiology; University Hospital Magdeburg; Magdeburg Germany

18. Internal Medicine I, Gastroenterology, Infectious Diseases; University Hospital Bonn; Bonn Germany

19. Internal Medicine Specialist Center Stresemannallee; Frankfurt am Main Germany

20. Practice Hohenstaufenring; Cologne Germany

21. Department of Medicine 3; University Medicine Erlangen; Erlangen Germany

22. Division of Infectious Diseases; University Hospital; Freiburg Germany

23. Department Internal Medicine I; University Regensburg; Regensburg Germany

24. Division of Infectiology and Pneumonology; Medical Department; Charité-University Medicine Berlin; Berlin Germany

25. Janssen-Cilag; Neuss Germany

Funder

Janssen-Cilag GmbH, Germany

Bundesministerium für Bildung und Forschung

Deutsches Zentrum für Infektionsforschung

Publisher

Wiley

Subject

Pharmacology (medical),Infectious Diseases,Health Policy

Reference27 articles.

1. Antiretroviral post-exposure prophylaxis (PEP) for occupational HIV exposure;Young;Cochrane Database Syst Rev,2007

2. Practical guidance for nonoccupational postexposure prophylaxis to prevent HIV infection: an editorial review;Jain;AIDS,2014

3. A case-control study of HIV seroconversion in health care workers after percutaneous exposure;Cardo;N Engl J Med,1997

4. Public Health Service guidelines for the management of health-care worker exposures to HIV and recommendations for postexposure prophylaxis;Centers for Disease Control and Prevention;MMWR Recomm Rep,1998

5. Seroconversion to HIV-1 following a needlestick injury despite combination post-exposure prophylaxis;Hawkins;J Infect,2001

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