Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity-Reference-Cited by-同舟云学术

Galacto‐conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity

Published:2020-03-31 Issue:4 Volume:19 Page:
ISSN:1474-9718
Container-title:Aging Cell
language:en
Short-container-title:Aging Cell

Author:

González‐Gualda Estela¹^ORCID,Pàez‐Ribes Marta¹,Lozano‐Torres Beatriz²³⁴⁵,Macias David¹,Wilson Joseph R.¹,González‐López Cristina¹,Ou Hui‐Ling¹,Mirón‐Barroso Sofía¹,Zhang Zhenguang¹,Lérida‐Viso Araceli⁵,Blandez Juan F.²,Bernardos Andrea²³⁴⁶,Sancenón Félix²³⁴⁵,Rovira Miguel⁷,Fruk Ljiljana⁸,Martins Carla P.⁹,Serrano Manuel⁷,Doherty Gary J.¹⁰,Martínez‐Máñez Ramón²³⁴⁵^ORCID,Muñoz‐Espín Daniel¹^ORCID

Affiliation:

1. CRUK Cambridge Centre Early Detection Programme Department of Oncology Hutchison/MRC Research Centre University of Cambridge Cambridge UK

2. Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico (IDM) Universitat Politècnica de València Universitat de València Valencia Spain

3. Unidad Mixta UPV‐CIPF de Investigación en Mecanismos de Enfermedades y Nanomedicina Centro de Investigación Príncipe Felipe Universitat Politècnica de València Valencia Spain

4. CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER‐BBN) Madrid Spain

5. Unidad Mixta de Investigación en Nanomedicina y Sensores IIS La Fe Universitat Politècnica de València Valencia Spain

6. Senolytic Therapeutics S.L. Parc Científic de Barcelona Barcelona Spain

7. Institute for Research in Biomedicine (IRB Barcelona) The Barcelona Institute of Science and Technology (BIST), Catalan Institution for Research and Advanced Studies (ICREA) Barcelona Spain

8. Department of Chemical Engineering and Biotechnology University of Cambridge Cambridge UK

9. Bioscience Oncology R&D AstraZeneca Cambridge UK

10. Department of Oncology Cambridge University Hospitals NHS Foundation Trust Addenbrooke's Hospital Cambridge UK

Funder

Royal Society

Medical Research Council

Cancer Research UK

Publisher

Wiley

Subject

Cell Biology,Aging

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/acel.13142

Reference42 articles.

1. Targeted Cargo Delivery in Senescent Cells Using Capped Mesoporous Silica Nanoparticles

2. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging

3. Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

4. ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

5. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

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