In‐field detection and characterization of B/Victoria lineage deletion variant viruses causing early influenza activity and an outbreak in Louisiana, 2019-Reference-Cited by-同舟云学术

In‐field detection and characterization of B/Victoria lineage deletion variant viruses causing early influenza activity and an outbreak in Louisiana, 2019

Published:2024-01 Issue:1 Volume:18 Page:
ISSN:1750-2640
Container-title:Influenza and Other Respiratory Viruses
language:en
Short-container-title:Influenza Resp Viruses

Author:

Shu Bo¹,Wilson Malania M.¹,Keller Matthew W.¹,Tran Ha²,Sokol Theresa³,Lee Grace³,Rambo‐Martin Benjamin L.¹,Kirby Marie K.¹^ORCID,Hassell Norman¹,Haydel Danielle²,Hand Julie³,Wentworth David E.¹,Barnes John R.¹

Affiliation:

1. Virology, Surveillance and Diagnosis Branch, Influenza Division Centers for Disease Control and Prevention Atlanta Georgia USA

2. Louisiana Department of Health Office of Public Health Laboratory Baton Rouge Louisiana USA

3. Louisiana Department of Health Office of Public Health, Infectious Disease Epidemiology New Orleans Louisiana USA

Abstract

AbstractBackgroundIn 2019, the Louisiana Department of Health reported an early influenza B/Victoria (B/VIC) virus outbreak.MethodAs it was an atypically large outbreak, we deployed to Louisiana to investigate it using genomics and a triplex real‐time RT‐PCR assay to detect three antigenically distinct B/VIC lineage variant viruses.ResultsThe investigation indicated that B/VIC V1A.3 subclade, containing a three amino acid deletion in the hemagglutinin and known to be antigenically distinct to the B/Colorado/06/2017 vaccine virus, was the most prevalent circulating virus within the specimens evaluated (86/88 in real‐time RT‐PCR).ConclusionThis work underscores the value of portable platforms for rapid, onsite pathogen characterization.

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/irv.13246

Reference13 articles.

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