Characteristics, toxicology and major organ pathology of deaths due to acute alcohol toxicity in Australia, 2011–2022

Abstract

AbstractIntroductionAcute alcohol toxicity is a significant component of alcohol‐related mortality. The study aimed to: (i) determine the circumstances of death and characteristics of fatal alcohol toxicity cases, 2011–2022; (ii) determine their toxicological profile and major autopsy findings; and (iii) determine trends in population mortality rates.MethodsRetrospective study of acute alcohol toxicity deaths in Australia, 2011–2022, retrieved from the National Coronial Information System.ResultsA total of 891 cases were identified, with a mean age of 49.2 years, 71.0% being male. Alcohol use problems were noted in 71.3%. In 57.5% death was attributed solely to acute alcohol toxicity, and combined acute alcohol toxicity/disease in 42.5%. There was evidence of sudden collapse in 24.9% of cases. The mean BAC was 0.331 g/100 mL (range 0.107–0.936), and spirits were the most commonly reported beverages (35.8%). Cases of combined toxicity/disease had significantly lower BACs than those attributed solely to alcohol toxicity (0.296 vs. 0.358 g/100 mL). Cardiomegaly was diagnosed in 32.5%, and severe coronary artery disease in 22.1%. Aspiration of vomitus was noted in 18.0%, and chronic obstructive pulmonary disease in 19.6%. Severe liver steatosis was present in 33.4% and 13.6% had cirrhosis. There was an average annual percentage increase in deaths of 7.90.Discussion and ConclusionsThe ‘typical’ case was a long‐standing, heavy spirits drinker. BACs showed enormous variation and no arbitrary concentration may be deemed lethal. Clinically significant disease was associated with death at a lower BAC and people with such disease may be at increased risk of alcohol poisoning.