Affiliation:
1. Department of Oral, Plastic and Aesthetic Surgery, Hospital of Stomatology Jilin University Changchun China
2. Key Laboratory of Automobile Materials of Ministry of Education, School of Materials Science and Engineering Jilin University Changchun China
Abstract
AbstractThe repair of bone defects from various causes remains a significant challenge in clinical settings. Piezoelectric materials have been demonstrated to promote osteogenic differentiation, among which barium titanate (BT) has been widely reported. Magnesium oxide (MgO) dopants not only enhance the piezoelectric properties but also stimulate the osteogenic and angiogenic properties in stem cells. In this study, a MgO‐modified BT/hydroxyapatite (MgO@BT/HA) piezoelectric ceramic scaffold was constructed using three‐dimensional (3D)‐printed technology. The results indicated that the addition of MgO improved the electrical properties of BT (d33 = 68.26 pC/N), and facilitated an increase in the proportion of HA (30%) while maintaining the piezoelectric coefficient (d33 = 2.04 pC/N) of the ceramic system. Furthermore, under the induction of low‐intensity pulsed ultrasound (LIPUS) stimulation, in vitro biosafety experiments confirmed that MgO@BT/HA exhibits excellent biosafety and promotes the osteogenic differentiation of dental pulp stem cells (DPSCs).
Funder
Ministry of Science and Technology of the People's Republic of China