Removal of site effects and enhancement of signal using dual projection independent component analysis for pooling multi‐site MRI data

Author:

Hao Yuxing1ORCID,Xu Huashuai2,Xia Mingrui345ORCID,Yan Chenwei1,Zhang Yunge1ORCID,Zhou Dongyue1,Kärkkäinen Tommi2,Nickerson Lisa D.67,Li Huanjie1ORCID,Cong Fengyu1289

Affiliation:

1. School of Biomedical Engineering, Faculty of Medicine Dalian University of Technology Dalian China

2. Faculty of Information Technology University of Jyväskylä Jyväskylä Finland

3. State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal University Beijing China

4. Beijing Key Laboratory of Brain Imaging and Connectomics Beijing Normal University Beijing China

5. IDG/McGovern Institute for Brain Research Beijing Normal University Beijing China

6. McLean Imaging Center, McLean Hospital Belmont Massachusetts USA

7. Department of Psychiatry Harvard Medical School Boston Massachusetts USA

8. School of Artificial Intelligence, Faculty of Electronic Information and Electrical Engineering Dalian University of Technology Dalian China

9. Key Laboratory of Integrated Circuit and Biomedical Electronic System, Liaoning Province. Dalian University of Technology Dalian China

Abstract

AbstractCombining magnetic resonance imaging (MRI) data from multi‐site studies is a popular approach for constructing larger datasets to greatly enhance the reliability and reproducibility of neuroscience research. However, the scanner/site variability is a significant confound that complicates the interpretation of the results, so effective and complete removal of the scanner/site variability is necessary to realise the full advantages of pooling multi‐site datasets. Independent component analysis (ICA) and general linear model (GLM) based harmonisation methods are the two primary methods used to eliminate scanner/site effects. Unfortunately, there are challenges with both ICA‐based and GLM‐based harmonisation methods to remove site effects completely when the signals of interest and scanner/site effects‐related variables are correlated, which may occur in neuroscience studies. In this study, we propose an effective and powerful harmonisation strategy that implements dual projection (DP) theory based on ICA to remove the scanner/site effects more completely. This method can separate the signal effects correlated with site variables from the identified site effects for removal without losing signals of interest. Both simulations and vivo structural MRI datasets, including a dataset from Autism Brain Imaging Data Exchange II and a travelling subject dataset from the Strategic Research Program for Brain Sciences, were used to test the performance of a DP‐based ICA harmonisation method. Results show that DP‐based ICA harmonisation has superior performance for removing site effects and enhancing the sensitivity to detect signals of interest as compared with GLM‐based and conventional ICA harmonisation methods.

Funder

National Natural Science Foundation of China

National Institutes of Health

Publisher

Wiley

Subject

General Neuroscience

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3