Semisynthetic triterpenes led to the generation of selective antitrypanosomal lead compounds

Author:

Guilhon‐Simplicio Fernanda1ORCID,Serrão Carlos Klinger Rodrigues1,Pinto Ana Cristina da Silva1,Pacheco Paulo Anastácio Furtado2,Faria Robson Xavier2,Rocha David Rodrigues2,Ferreira Vitor Francisco3,Pereira‐Junior Raimundo Carlos4,Matheeussen An5,Baán Adrienn6,Kiekens Filip6,Meneses Pereira Maria1,Lima Emerson Silva1,Winter Hans De7,Cos Paul5

Affiliation:

1. Faculty of Pharmaceutical Sciences Federal University of Amazonas Manaus Brazil

2. Department of Chemistry Fluminense Federal University Niterói Brazil

3. Faculty of Pharmacy Fluminense Federal University Niterói Brazil

4. Superior Studies Center Amazonas State University Tefé Brazil

5. Laboratory of Microbiology, Parasitology and Hygiene (LMPH) Faculty of Pharmaceutical, Biomedical and Veterinary Sciences University of Antwerp Wilrijk Belgium

6. Laboratory of Pharmaceutical Technology and Biopharmacy Faculty of Pharmaceutical, Biomedical and Veterinary Sciences University of Antwerp Wilrijk Belgium

7. Laboratory of Medicinal Chemistry Faculty of Pharmaceutical, Biomedical and Veterinary Sciences University of Antwerp Wilrijk Belgium

Funder

Fundação de Amparo à Pesquisa do Estado do Amazonas

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

Wiley

Subject

Molecular Medicine,Biochemistry,Drug Discovery,Pharmacology,Organic Chemistry

Reference40 articles.

1. A possible mechanism for anxiolytic and antidepressant effects of alpha- and beta-amyrin from Protium heptaphyllum (Aubl.) March

2. Obtenção de derivados da mistura triterpenoídica alfa- e beta-amirina

3. Amyrin esters induce cell death by apoptosis in HL-60 leukemia cells

4. Anti‐trypanosoma activity and synergistic effects of natural and semi‐synthetic triterpenes and predominant cell death through autophagy in amastigote forms;Bossolani G.;Journal of the Brazilian Chemical Society,2017

5. Steroidal Oximes: Useful Compounds with Antitumor Activities

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