Molecular Classifiers for Acute Kidney Transplant Rejection in Peripheral Blood by Whole Genome Gene Expression Profiling

Author:

Kurian S. M.12,Williams A. N.12,Gelbart T.32,Campbell D.32,Mondala T. S.32,Head S. R.32,Horvath S.42,Gaber L.52,Thompson R.1,Whisenant T.1,Lin W.42,Langfelder P.42,Robison E. H.32,Schaffer R. L.62,Fisher J. S.62,Friedewald J.7,Flechner S. M.82,Chan L. K.92,Wiseman A. C.92,Shidban H.102,Mendez R.102,Heilman R.112,Abecassis M. M.7,Marsh C. L.62,Salomon D. R.162

Affiliation:

1. Department of Molecular and Experimental Medicine; The Scripps Research Institute; La Jolla CA

2. Transplant Genomics Collaborative Group (TGCG)

3. DNA Array Core; The Scripps Research Institute; La Jolla CA

4. Department of Biostatistics; University of California; Los Angeles CA

5. The Texas Medical Center; Houston TX

6. Scripps Center for Organ Transplantation; Scripps Health; La Jolla CA

7. Northwestern Comprehensive Transplant Center; Northwestern University; Chicago IL

8. Glickman Urological Institute; The Cleveland Clinic; Cleveland OH

9. University of Colorado Hospital; Transplant Services; Aurora CO

10. St. Vincent Medical Center; Kidney Transplantation; Los Angeles CA

11. Department of Medicine; Mayo Clinic Arizona and Mayo Clinic College of Medicine; Phoenix AZ

Funder

National Institutes of Health

Publisher

Wiley

Subject

Pharmacology (medical),Transplantation,Immunology and Allergy

Reference39 articles.

1. Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era;Meier-Kriesche;Am J Transplant,2004

2. Subclinical rejection-A potential surrogate marker for chronic rejection-May be diagnosed by protocol biopsy or urine spectroscopy;Rush;Ann Transplant,2000

3. Subclinical rejection associated with chronic allograft nephropathy in protocol biopsies as a risk factor for late graft loss;Moreso;Am J Transplant,2006

4. Subclinical renal allograft rejection and protocol biopsies: Quo vadis;Nankivell;Nat Clin Pract Nephrol,2008

5. US Department of Health and Human Services http://www.ustransplant.org/annual_reports/current/509a_ki.htm

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