Infliximab Inhibits Activation and Effector Functions of Peripheral Blood T Cellsin vitrofrom Patients with Clinically Active Ulcerative Colitis

Author:

Dahlén R.12,Strid H.1,Lundgren A.2,Isaksson S.12,Raghavan S.2,Magnusson M. K.12,Simrén M.1,Sjövall H.1,Öhman L.12

Affiliation:

1. Department of Internal Medicine and Clinical Nutrition; Sahlgrenska Academy; University of Gothenburg; Gothenburg Sweden

2. Department of Microbiology and Immunology; Sahlgrenska Academy; University of Gothenburg; Gothenburg Sweden

Funder

Swedish Medical Research Council

Health & Medical Care Committee of the Regional Executive Board

Mag-Tarm Fonden

The Swedish Society of Medicine

MIVAC

Foundations of Nanna Svartz

Magnus Bergvall

Sahlgrenska Academy Hospital

Tore Nilsson

Wilhelm and Martina Lundgren, Golje

Publisher

Wiley

Subject

Immunology,General Medicine

Reference28 articles.

1. Disparate CD4 +  lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5;Fuss;J Immunol,1996

2. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution;Heller;Gastroenterology,2005

3. The fundamental basis of inflammatory bowel disease;Strober;J Clin Invest,2007

4. Medical therapy for ulcerative colitis 2004;Hanauer;Gastroenterology,2004

5. Infliximab as rescue therapy in severe to moderately severe ulcerative colitis: a randomized, placebo-controlled study;Järnerot;Gastroenterology,2005

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