Characterization of platelet factor 4 amino acids that bind pathogenic antibodies in heparin‐induced thrombocytopenia-Reference-Cited by-同舟云学术

Characterization of platelet factor 4 amino acids that bind pathogenic antibodies in heparin‐induced thrombocytopenia

Published:2019-02 Issue:2 Volume:17 Page:389-399
ISSN:1538-7933
Container-title:Journal of Thrombosis and Haemostasis
language:en
Short-container-title:J Thromb Haemost

Author:

Huynh Angela¹,Arnold Donald M.¹²³,Kelton John G.¹,Smith James W.¹,Horsewood Peter¹,Clare Rumi¹,Guarné Alba⁴,Nazy Ishac¹²

Affiliation:

1. Department of Medicine Michael G. DeGroote School of Medicine McMaster University Hamilton Ontario Canada

2. McMaster Centre for Transfusion Research Hamilton Ontario Canada

3. Canadian Blood Services Hamilton Ontario Canada

4. Department of Biochemistry and Biomedical Sciences McMaster University Hamilton Ontario Canada

Funder

Canadian Institutes of Health Research

McMaster University

Publisher

Wiley

Subject

Hematology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/jth.14369

Reference50 articles.

1. Risk for heparin-induced thrombocytopenia with unfractionated and low-molecular-weight heparin thromboprophylaxis: a meta-analysis

2. Heparin-induced thrombocytopenia: a historical perspective

3. Platelet Factor 4 Complexed to Heparin Is the Target for Antibodies Generated in Heparin-Induced Thrombocytopenia

4. Antibodies from patients with heparin-induced thrombocytopenia/thrombosis are specific for platelet factor 4 complexed with heparin or bound to endothelial cells.

5. Heparin‐associated thrombocytopenia: isolation of the antibody and characterization of a multimolecular PF4‐heparin complex as the major antigen;Greinacher A;Thromb Haemost,1994

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