Neutrophilia, gelatinase release and microvascular leakage induced by human mast cell tryptase in a mouse model: Lack of a role of protease-activated receptor 2 (PAR2)

Author:

Khedr M. E. M. S.12,Abdelmotelb A. M.13,Pender S. L. F.1,Zhou X.1,Walls A. F.1ORCID

Affiliation:

1. Clinical and Experimental Sciences Academic Unit; Faculty of Medicine; University of Southampton; Southampton UK

2. Faculty of Medicine; Suez Canal University; Ismailia Egypt

3. Faculty of Medicine; Tanta University; Tanta Egypt

Funder

Ministry of Higher Education

Asthma UK

Medical Research Council

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference67 articles.

1. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2;Corvera;J Clin Invest,1997

2. Interactions of mast cell tryptase with thrombin receptors and PAR-2;Molino;J Biol Chem,1997

3. Mitogenic responses mediated through the proteinase-activated receptor-2 are induced by expressed forms of mast cell alpha- or beta-tryptases;Mirza;Blood,1997

4. Thrombin and trypsin induce granulocyte-macrophage colony-stimulating factor and interleukin-6 gene expression in cultured normal human keratinocytes;Wakita;Proc Assoc Am Physicians,1997

5. Airway epithelial cells release eosinophil survival-promoting factors (GM-CSF) after stimulation of proteinase-activated receptor 2;Vliagoftis;J Allergy Clin Immunol,2001

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