Brief report: The influence of childhood trauma on the effects of delta‐9‐tetrahydrocannabinol in persons with opioid use disorder-Reference-Cited by-同舟云学术

Brief report: The influence of childhood trauma on the effects of delta‐9‐tetrahydrocannabinol in persons with opioid use disorder

Published:2023-12-07 Issue: Volume: Page:
ISSN:1055-0496
Container-title:The American Journal on Addictions
language:en
Short-container-title:American J Addict

Author:

Rogan Michael¹²,Nunes Julio C.¹²,Xie Catherine Z.³,Sofuoglu Mehmet¹²,Pittman Brian¹,De Aquino Joao P.¹²⁴^ORCID

Affiliation:

1. Department of Psychiatry Yale University School of Medicine New Haven Connecticut USA

2. VISN‐1 Mental Illness Research Education and Clinical Center (MIRECC) VA Connecticut Healthcare System West Haven Connecticut USA

3. Department of Counseling and Developmental Psychology Boston College Chestnut Hill Massachusetts USA

4. Clinical Neuroscience Research Unit Connecticut Mental Health Center New Haven Connecticut USA

Abstract

AbstractBackground and ObjectivesChildhood trauma (CT) increases addiction vulnerability. We examined CT's impact on delta‐9‐tetrahydrocannabinol (THC) effects.MethodsThis is a post‐hoc analysis of a randomized, placebo‐controlled, crossover trial investigating the effects of oral THC (10, 20 mg) among 25 persons receiving methadone for opioid use disorder (OUD).ResultsGreater CT was associated with lower aversive effects from higher THC doses (20 mg) (p = .006).Discussion and ConclusionsCT may reduce the subjective aversive effects of THC, potentially leading to greater cannabis use in individuals with OUD.Scientific SignificanceThese findings offer insights into THC's risks versus benefits in OUD subgroups and emphasize assessing CT in OUD treatment and research.

Publisher

Wiley

Subject

Psychiatry and Mental health,Clinical Psychology,Medicine (miscellaneous)

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/ajad.13504

Reference10 articles.

1. National Institutes of Health National Institute on Drug Abuse. Drug overdose death rates2023.https://nida.nih.gov/research-topics/trends-statistics/overdose-death-ratesates. 2023. Accessed June 23 2023.

2. Opioid-induced analgesia among persons with opioid use disorder receiving methadone or buprenorphine: A systematic review of experimental pain studies

3. Emerging Evidence for Cannabis' Role in Opioid Use Disorder

4. Association Between US State Medical Cannabis Laws and Opioid Prescribing in the Medicare Part D Population

5. A randomised, double‐blind study investigating the relationship between early childhood trauma and the rewarding effects of morphine