Rapid loss of response after withdrawal of treatment with azacitidine: a case series in patients with higher-risk myelodysplastic syndromes or chronic myelomonocytic leukemia

Author:

Voso Maria Teresa1,Breccia Massimo2,Lunghi Monia3,Poloni Antonella4,Niscola Pasquale5,Finelli Carlo6,Bari Alessia7,Musto Pellegrino8,Zambello Renato9,Fianchi Luana1,Alimena Giuliana2,Leone Giuseppe1

Affiliation:

1. Department of Hematology; Universita' Cattolica S. Cuore; Rome; Italy

2. Department of Hematology; Università La Sapienza; Rome; Italy

3. Department of Hematology; Università del Piemonte Orientale Amedeo Avogadro; Novara; Italy

4. Department of Hematology; Università Politecnica delle Marche; Ancona; Italy

5. Department of Hematology; Ospedale S. Eugenio; Roma; Italy

6. Department of Hematology; Universita' di Bologna; Bologna; Italy

7. Department of Hematology; Universita' di Modena and Reggio Emilia; Modena; Italy

8. Unità di Ematologia e Trapianto di Cellule Staminali; IRCCS; Centro di Riferimento Oncologico della Basilicata; Rionero in Vulture; Italy

9. Department of Clinical and Experimental Medicine; University of Padova; Padova; Italy

Publisher

Wiley

Subject

Hematology,General Medicine

Reference16 articles.

1. Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study;Fenaux;Lancet Oncol,2009

2. Effects of azacitidine compared with conventional care regimens in elderly (≥ 75 years) patients with higher-risk myelodysplastic syndromes;Seymour;Crit Rev Oncol Hematol,2010

3. Comorbidities influence prognosis in MDS high-risk patients treated with 5-azacitidine;Sanna;Haematologica,2011

4. Vidaza Summary of Product Characteristics http://www.medicines.org.uk/EMC/medicine/21508/SPC/Vidaza%2025%20mg%20ml%20powder%20for%20suspension%20for%20injection/

5. Continued azacitidine therapy beyond time of first response improves quality of response in patients with higher-risk myelodysplastic syndromes;Silverman;Cancer,2011

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