Fostemsavir and ethinyl estradiol drug interaction: Clinical recommendations for co‐administration

Author:

Nwokolo Nneka1ORCID,Post Elana2,Mageau A. Savannah2,Shah Rimi1,Magee Mindy3,Mannino Frank4,Ackerman Peter5,Clark Andrew1,Moore Katy2

Affiliation:

1. Global Medical, ViiV Healthcare Brentford UK

2. Clinical Pharmacology, ViiV Healthcare Durham North Carolina USA

3. Clinical Pharmacology Modeling and Simulation, GSK Upper Providence Pennsylvania USA

4. Clinical Statistics, GSK Upper Providence Pennsylvania USA

5. Clinical Development ViiV Healthcare Branford Connecticut USA

Funder

ViiV Healthcare

Publisher

Wiley

Subject

Pharmacology (medical),Infectious Diseases,Health Policy

Reference13 articles.

1. Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action

2. Compartmental Absorption Modeling and Site of Absorption Studies to Determine Feasibility of an Extended-Release Formulation of an HIV-1 Attachment Inhibitor Phosphate Ester Prodrug

3. KozalM AbergJ PialouxG et al.Phase 3 study of fostemsavir in heavily treatment‐experienced HIV‐1‐infected participants: day 8 and week 24 primary efficacy and safety results (BRIGHTE study formerly 205888/AI438‐047). Slides presented at: 16th European AIDS Conference; October 25–27 2017; Milan Italy.

4. Effect of Renal and Hepatic Impairment on the Pharmacokinetics of Temsavir, the Active Moiety of Fostemsavir

5. Rukobia [prescribing information].Research TrianglePark NC: ViiV Healthcare;2022.

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