Current and future treatment for alcoholic‐related liver diseases

Author:

Yoon Eileen L.12,Kim Won3ORCID

Affiliation:

1. Department of Internal Medicine Hanyang University College of Medicine Seoul Republic of Korea

2. Hanyang Institute of Bioscience and Biotechnology Hanyang University Seoul Republic of Korea

3. Department of Internal Medicine Seoul National University College of Medicine and Seoul Metropolitan Government Boramae Medical Center Seoul Republic of Korea

Abstract

AbstractThe socioeconomic burden of alcohol‐related liver disease has been increasing worldwide. Its prevalence is underestimated, and patients with alcohol‐related liver disease are rarely diagnosed in the earlier phase of the disease spectrum. Alcoholic hepatitis is a distinct syndrome with life‐threatening signs of systemic inflammation. In severe alcoholic hepatitis, prednisolone is indicated as the first‐line treatment even with the possibility of various complications. Early liver transplantation can be another option for highly selected patients with a null response to prednisolone. Most importantly, abstinence is the mainstay of long‐term care, but relapse is frequent among patients. Recent findings on the pathogenesis of alcoholic hepatitis have enabled us to discover new therapeutic targets. Preventing hepatic inflammation, reducing oxidative stress, improving gut dysbiosis, and enhancing liver regeneration are the main targets of emerging therapies. Herein, we review the pathogenesis, current treatment, and barriers to successful clinical trials of alcoholic hepatitis. Additionally, clinical trials for alcoholic hepatitis, either ongoing or recently completed, will be briefly introduced.

Publisher

Wiley

Subject

Gastroenterology,Hepatology

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