Inhibition of related JAK/STAT pathways with molecular targeted drugs shows strong synergy with ruxolitinib in chronic myeloproliferative neoplasm
Author:
Affiliation:
1. Haematology Service; Hospital Universitario 12 de Octubre; Madrid; Spain
2. Hospital Principe de Asturias; Alcala de Henares; Madrid; Spain
Publisher
Wiley
Subject
Hematology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bjh.12308/fullpdf
Reference36 articles.
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2. Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders;Baxter;Lancet,2005
3. Reciprocal regulation of c-Src and STAT3 in non-small cell lung cancer;Byers;Clinical Cancer Research,2009
4. Developmental changes in the expression of transcription factors GATA-1, -2 and -3 during the onset of human medullary haematopoiesis;Dame;British Journal of Haematology,2002
5. FLT3-mediated p38-MAPK activation participates in the control of megakaryopoiesis in primary myelofibrosis;Desterke;Cancer Research,2011
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