A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia-Reference-Cited by-同舟云学术

A randomized phase I/II trial of HQK-1001, an oral fetal globin gene inducer, in β-thalassaemia intermedia and HbE/β-thalassaemia

Published:2013-03-27 Issue:4 Volume:161 Page:587-593
ISSN:0007-1048
Container-title:British Journal of Haematology
language:en
Short-container-title:Br J Haematol

Author:

Fucharoen Suthat¹,Inati Adlette²,Siritanaratku Noppadol¹,Thein Swee L.³,Wargin William C.⁴,Koussa Suzanne²,Taher Ali²,Chaneim Nattawara¹,Boosalis Michael⁵,Berenson Ronald⁶,Perrine Susan P.⁵

Affiliation:

1. Thalassemia Research Centre; Mahidol University; Nakhonpathon Thailand

2. Chronic Care Centre and Rafik Hariri Hospital; Beirut Lebanon

3. King's College Hospital; London UK

4. PK-PM Associates; Chapel Hill NC USA

5. Boston University School of Medicine; Boston MA USA

6. HemaQuest Pharmaceuticals; San Diego CA USA

Publisher

Wiley

Subject

Hematology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/bjh.12304/fullpdf

Reference35 articles.

1. Novel therapeutic candidates, identified by molecular modeling, induce fetal globin gene expression in vivo;Boosalis;Blood Cells, Molecules & Diseases,2011

2. Administration of high doses of recombinant human erythropoietin to patients with beta- thalassemia intermedia: a preliminary trial;Bourantas;European Journal of Haematology,1997

3. Oral isobutyramide therapy in patients with thalassemia intermedia: results of a phase II open study;Cappellini;Blood Cells, Molecules and Diseases,2000

4. Enhancement of growth and survival and alterations in Bcl-family proteins in beta-thalassemic erythroid progenitors by novel short-chain fatty acid derivatives;Castaneda;Blood Cells, Molecules and Diseases,2005

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