Printable oxygen‐generating biodegradable scaffold for thicker tissue‐engineered medical products

Abstract

AbstractBackgroundDue to the increasing demand to generate thick and vascularized tissue‐engineered constructs, novel strategies are currently being developed. An effective example is the fabrication of a 3D scaffold containing oxygen‐releasing biomaterials to solve the limitations of gas diffusion and transport within transplanted tissues or devices.MethodsIn this study, we developed a biodegradable scaffold made of polycaprolactone (PCL) mixed with oxygen‐generating calcium peroxide (CPO) to design new structures for regenerative tissue using a 3D printer capable of forming arbitrarily shapes.Results and ConclusionWhen osteoblast progenitor cells (MC3T3‐E1 cells) were cultured under hypoxic conditions on scaffolds fabricated with this technique, it was shown that cell death was reduced by the new scaffolds. Therefore, the results suggest that 3D‐printed scaffolds made from biodegradable oxygen‐releasing materials may be useful for tissue engineering and regeneration.