Mechanistic Modeling of Intra‐Tumor Spatial Distribution of Antibody‐Drug Conjugates: Insights into Dosing Strategies in Oncology-Reference-Cited by-同舟云学术

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Mechanistic Modeling of Intra‐Tumor Spatial Distribution of Antibody‐Drug Conjugates: Insights into Dosing Strategies in Oncology

Published:2020-10-19 Issue:1 Volume:14 Page:395-404
ISSN:1752-8054
Container-title:Clinical and Translational Science
language:en
Short-container-title:Clin Transl Sci

Author:

Weddell Jared¹,Chiney Manoj S.¹,Bhatnagar Sumit¹,Gibbs John P.¹,Shebley Mohamad¹

Affiliation:

1. Clinical Pharmacology and Pharmacometrics AbbVie Inc. North Chicago Illinois USA

Funder

AbbVie

Publisher

Wiley

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine,General Neuroscience

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/cts.12892

Reference46 articles.

1. Sacituzumab govitecan, a novel, third-generation, antibody-drug conjugate (ADC) for cancer therapy

2. Current Trends in the Clinical Development of Antibody-Drug Conjugates in Oncology

3. Improved Tumor Penetration and Single-Cell Targeting of Antibody–Drug Conjugates Increases Anticancer Efficacy and Host Survival

4. Bench to bedside translation of antibody drug conjugates using a multiscale mechanistic PK/PD model: a case study with brentuximab-vedotin

5. A Priori Prediction of Tumor Payload Concentrations: Preclinical Case Study with an Auristatin-Based Anti-5T4 Antibody-Drug Conjugate

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