Affiliation:
1. Department of Microbiology, Immunology and Molecular Genetics University of California Los Angeles California USA
2. Department of Molecular and Medical Pharmacology University of California Los Angeles California USA
Abstract
SummaryThe mevalonate pathway is an essential metabolic pathway in T cells regulating development, proliferation, survival, differentiation, and effector functions. The mevalonate pathway is a complex, branched pathway composed of many enzymes that ultimately generate cholesterol and nonsterol isoprenoids. T cells must tightly control metabolic flux through the branches of the mevalonate pathway to ensure sufficient isoprenoids and cholesterol are available to meet cellular demands. Unbalanced metabolite flux through the sterol or the nonsterol isoprenoid branch is metabolically inefficient and can have deleterious consequences for T cell fate and function. Accordingly, there is tight regulatory control over metabolic flux through the branches of this essential lipid synthetic pathway. In this review we provide an overview of how the branches of the mevalonate pathway are regulated in T cells and discuss our current understanding of the relationship between mevalonate metabolism, cholesterol homeostasis and T cell function.
Funder
Howard Hughes Medical Institute
National Heart, Lung, and Blood Institute
Subject
Immunology,Immunology and Allergy
Cited by
2 articles.
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