Fibroblast‐specific genome‐scale modelling predicts an imbalance in amino acid metabolism in Refsum disease

Author:

Wegrzyn Agnieszka B.12ORCID,Herzog Katharina34,Gerding Albert15,Kwiatkowski Marcel67,Wolters Justina C.8,Dolga Amalia M.9,Lint Alida E. M.3,Wanders Ronald J. A.3,Waterham Hans R.3,Bakker Barbara M.1

Affiliation:

1. Systems Medicine of Metabolism and Signalling Laboratory of Paediatrics University of GroningenUniversity Medical Centre GroningenThe Netherlands

2. Analytical Biosciences and Metabolomics Division of Systems Biomedicine and Pharmacology Leiden Academic Centre for Drug Research Leiden University The Netherlands

3. Laboratory Genetic Metabolic Diseases Department of Clinical Chemistry Amsterdam UMC, Location AMC University of Amsterdam The Netherlands

4. Centre for Analysis and Synthesis Department of Chemistry Lund University Sweden

5. Department of Laboratory Medicine University of Groningen University Medical Center Groningen The Netherlands

6. Pharmacokinetics, Toxicology and Targeting Groningen Research Institute of Pharmacy (GRIP) University of Groningen The Netherlands

7. Mass Spectrometric Proteomics and Metabolomics Institute of Biochemistry University of Innsbruck Austria

8. Laboratory of Paediatrics University Medical Centre Groningen University of Groningen The Netherlands

9. Department of Molecular Pharmacology Groningen Research Institute of Pharmacy University of Groningen The Netherlands

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

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