Reversible inhibition of the glycine transporter GlyT2 circumvents acute toxicity while preserving efficacy in the treatment of pain
Author:
Affiliation:
1. New Medicines; UCB; Braine-L'Alleud; Belgium
Publisher
Wiley
Subject
Pharmacology
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1111/bph.12343/fullpdf
Reference43 articles.
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2. Molecular basis for proton regulation of glycine transport by glycine transporter subtype 1b;Aubrey;Mol Pharmacol,2000
3. Cellular and molecular mechanisms of pain;Basbaum;Cell,2009
4. Cyclooxygenase inhibitors: instrumental drugs to understand cardiovascular homeostasis and arterial thrombosis;Bunimov;Cardiovasc Hematol Disord Drug Targets,2008
5. The first potent and selective inhibitors of the glycine transporter type 2;Caulfield;J Med Chem,2001
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1. The efficacy of the analgesic GlyT2 inhibitor, ORG25543, is determined by two connected allosteric sites;Journal of Neurochemistry;2023-12-22
2. Analysis of Binding Determinants for Different Classes of Competitive and Noncompetitive Inhibitors of Glycine Transporters;International Journal of Molecular Sciences;2022-07-21
3. Peripheral Administration of Selective Glycine Transporter-2 Inhibitor, Oleoyl-D-Lysine, Reverses Chronic Neuropathic Pain but Not Acute or Inflammatory Pain in Male Mice;Journal of Pharmacology and Experimental Therapeutics;2022-07-02
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