Genetic inhibition of PDK1 robustly reduces plaque deposition and ameliorates gliosis in the 5×FAD mouse model of Alzheimer's disease-Reference-Cited by-同舟云学术

Genetic inhibition of PDK1 robustly reduces plaque deposition and ameliorates gliosis in the 5×FAD mouse model of Alzheimer's disease

Published:2022-07-31 Issue:7 Volume:48 Page:
ISSN:0305-1846
Container-title:Neuropathology and Applied Neurobiology
language:en
Short-container-title:Neuropathology Appl Neurobio

Author:

Ye Xiaolian¹,Chen Lu¹,Wang He²,Peng Shixiao¹,Liu Mengjia¹,Yao Liyang¹,Zhang Yizhi¹,Shi Yun Stone¹,Cao Ying¹,Yang Jian‐Jun²,Chen Guiquan¹^ORCID

Affiliation:

1. MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Jiangsu Key Laboratory of Molecular Medicine Medical School, Nanjing University Nanjing China

2. Department of Anesthesiology, Pain and Perioperative Medicine The First Affiliated Hospital of Zhengzhou University Zhengzhou China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Fundamental Research Funds for the Central Universities

Publisher

Wiley

Subject

Physiology (medical),Neurology (clinical),Neurology,Histology,Pathology and Forensic Medicine

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/nan.12839

Reference78 articles.

1. Axon–glial disruption: the link between vascular disease and Alzheimer's disease?

2. The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

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