Affiliation:
1. Department of Cardiology Peking University Third Hospital Beijing P.R. China
2. Department of Critical Care Medicine, Shenzhen People's Hospital Second Clinical Medical College of Jinan University, First Affiliated Hospital of Southern University of Science and Technology Shenzhen P.R. China
3. Department of Geriatrics The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital Shenzhen P.R. China
Abstract
AbstractCathepsin B (CTSB) is a member of the cysteine protease family, primarily responsible for degrading unnecessary organelles and proteins within the acidic milieu of lysosomes to facilitate recycling. Recent research has revealed that CTSB plays a multifaceted role beyond its function as a proteolytic enzyme in lysosomes. Importantly, recent data suggest that CTSB has significant impacts on different cardiac pathological conditions, such as atherosclerosis (AS), myocardial infarction, hypertension, heart failure and cardiomyopathy. Especially in the context of AS, preclinical models and clinical sample imaging data indicate that the cathepsin activity‐based probe can reliably image CTSB activity in foam cells and atherosclerotic plaques; concurrently, it allows synchronous diagnostic and therapeutic interventions. However, our knowledge of CTSB in cardiovascular disease is still in the early stage. This paper aims to provide a comprehensive review of the significance of CTSB in cardiovascular physiology and pathology, with the objective of laying a theoretical groundwork for the development of drugs targeting CTSB.
Funder
National Natural Science Foundation of China
Sanming Project of Medicine in Shenzen Municipality