A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models-Reference-Cited by-同舟云学术

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A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models

Published:2016-04-16 Issue:5 Volume:40 Page:945-954
ISSN:0145-6008
Container-title:Alcoholism: Clinical and Experimental Research
language:en
Short-container-title:Alcohol Clin Exp Res

Author:

Rorick-Kehn Linda M.¹,Ciccocioppo Roberto²,Wong Conrad J.¹,Witkin Jeffrey M.¹,Martinez-Grau Maria A.³,Stopponi Serena²,Adams Benjamin L.¹,Katner Jason S.¹,Perry Kenneth W.¹,Toledo Miguel A.³,Diaz Nuria³,Lafuente Celia³,Jiménez Alma³,Benito Ana³,Pedregal Concepción³,Weiss Friedbert⁴,Statnick Michael A.¹

Affiliation:

1. Lilly Research Laboratories; Eli Lilly and Company; Indianapolis Indiana

2. School of Pharmacy; Pharmacology Unit; University of Camerino; Camerino Italy

3. Eli Lilly and Company; Madrid Spain

4. Department of Molecular and Cellular Neurosciences; The Scripps Research Institute; La Jolla California

Funder

Eli Lilly and Co., Indianapolis, IN, USA

NIH/NIAAA

Publisher

Wiley

Subject

Psychiatry and Mental health,Toxicology,Medicine (miscellaneous)

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1111/acer.13052/fullpdf

Reference45 articles.

1. A critique of fixed and progressive ratio schedules used to examine the neural substrates of drug reinforcement;Arnold;Pharmacol Biochem Behav,1997

2. [3H]-nociceptin ligand-binding and nociceptin opioid receptor mrna expression in the human brain;Berthele;Neuroscience,2003

3. Regional differences in the regulation of dopamine and noradrenaline release in medial frontal cortex, nucleus accumbens and caudate-putamen: a microdialysis study in the rat;Cenci;Brain Res,1992

4. Quantitative signaling and structure-activity analyses demonstrate functional selectivity at the nociceptin/orphanin FQ opioid receptor;Chang;Mol Pharmacol,2015

5. Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats;Ciccocioppo;Psychopharmacology,2004

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