An unbalanced monocyte macrophage polarization in the bone marrow microenvironment of patients with poor graft function after allogeneic haematopoietic stem cell transplantation

Author:

Zhao Hong-Yan1,Lyu Zhong-Shi12,Duan Cai-Wen3,Song Yang12,Han Ting-Ting1,Mo Xiao-Dong1,Wang Yu1,Xu Lan-Ping1ORCID,Zhang Xiao-Hui1ORCID,Huang Xiao-Jun12,Kong Yuan1ORCID

Affiliation:

1. Peking University People's Hospital; Peking University Institute of Hematology; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation; Collaborative Innovation Center of Hematology; Peking University; Beijing China

2. Peking-Tsinghua Center for Life Sciences; Academy for Advanced Interdisciplinary Studies; Peking University; Beijing China

3. Key Laboratory of Pediatric Hematology and Oncology Ministry of Health and Pediatric Translational Medicine Institute; Shanghai Children's Medical Center; Shanghai Collaborative Innovation Center for Translational Medicine and Department of Pharmacology and Chemical Biology; Shanghai Jiao Tong University School of medicine; Shanghai China

Funder

National Natural Science Foundation of China

Peking University

National Key Research and Development Program

Stem Cell and Translation Research

Science and Technology Project of Guangdong Province of China

Publisher

Wiley

Subject

Hematology

Reference53 articles.

1. Positive and negative effects of tumor necrosis factor on colony growth from highly purified normal marrow progenitors;Backx;Leukemia,1991

2. The suppressive influences of human tumor necrosis factors on bone marrow hematopoietic progenitor cells from normal donors and patients with leukemia: synergism of tumor necrosis factor and interferon-gamma;Broxmeyer;The Journal of Immunology,1986

3. The hematopoietic stem cell niche in homeostasis and disease;Calvi;Blood,2015

4. Osteoblastic cells regulate the haematopoietic stem cell niche;Calvi;Nature,2003

5. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche;Chow;Journal of Experimental Medicine,2011

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