Trends in reported GHB‐related presentations to Sydney emergency departments between 2012 and 2021

Author:

Harris Oliver1,Siefried Krista J234,Chiew Angela5ORCID,Jamshidi Nazila67,Chung Daniel T5,Moore Nicholas8ORCID,Nic Ionmhain Una8,Roberts Darren M69ORCID,Ezard Nadine23410ORCID,Brett Jonathan111ORCID

Affiliation:

1. St Vincent's Clinical School The University of New South Wales Sydney New South Wales Australia

2. Alcohol and Drug Service St Vincent's Hospital Sydney Sydney New South Wales Australia

3. The National Centre for Clinical Research on Emerging Drugs of Concern (NCCRED) c/o The University of New South Wales Sydney New South Wales Australia

4. The National Drug and Alcohol Research Centre (NDARC) The University of New South Wales Sydney New South Wales Australia

5. Toxicology Department Prince of Wales Hospital Sydney New South Wales Australia

6. Drug Health Department Royal Prince Alfred Hospital Sydney New South Wales Australia

7. Clinical Pharmacology and Drug Health Services Sydney Local Health Districy Sydney New South Wales Australia

8. Clinical Toxicology & Emergency Medicine, Liverpool Hospital Sydney New South Wales Australia

9. New South Wales Poison's Information Centre Sydney Children's Hospital Weastmead Sydney New South Wales Australia

10. Drug and Alcohol Clinical Research and Improvement Network (DACRIN) Sydney New South Wales Australia

11. Department of Clinical Pharmacology and Toxicology St Vincent's Hospital Sydney Sydney New South Wales Australia

Abstract

AbstractObjectivesIn overdose, gamma‐hydroxybutyrate (GHB) and its precursors can cause decreased levels of consciousness, coma and death. Here, we aim to describe reported exposure to GHB at four EDs in Sydney, New South Wales (NSW), Australia.MethodsWe searched the ED databases of four Sydney metropolitan hospitals for presentations relating to GHB exposure between 2012 and 2021. We calculated annual number of presentations stratified by hospital, age, sex, mode of arrival and triage category.ResultsA total of 3510 GHB‐related presentations to ED were recorded across the four hospitals. Data for all hospitals were only available from 2015 onwards and between 2015 and 2021; there was a 114% increase in annual presentations (from 228 to 487). Males represented 68.7% of all presentations and the median age was 31 years (range 16–74 years). There was an increase in the proportion of female presentations between 2012 and 2021 (from 27.9% to 37.9%) along with the severity of presentation over the same period, with the proportion of presentations with a triage category 1 increasing from 19.7% to 34.5%.ConclusionsIncreases in recorded absolute number and severity of GHB‐related presentations to Sydney EDs are a major public health concern. There may also be shifts in the demographics of those with GHB‐related presentations. Renewed efforts are required to understand the drivers of these increases to optimally target harm reduction approaches.

Funder

National Health and Medical Research Council

Publisher

Wiley

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