Physiologically based pharmacokinetic modelling of treprostinil after intravenous injection and extended‐release oral tablet administration in healthy volunteers: An extrapolation to other patient populations including patients with hepatic impairment-Reference-Cited by-同舟云学术

Physiologically based pharmacokinetic modelling of treprostinil after intravenous injection and extended‐release oral tablet administration in healthy volunteers: An extrapolation to other patient populations including patients with hepatic impairment

Published:2021-07-23 Issue:2 Volume:88 Page:587-599
ISSN:0306-5251
Container-title:British Journal of Clinical Pharmacology
language:en
Short-container-title:Brit J Clinical Pharma

Author:

Wu Xuemei¹²^ORCID,Zhang Xiaohan³,Xu Ruichao¹,Shaik Imam Hussain¹^ORCID,Venkataramanan Raman¹⁴⁵^ORCID

Affiliation:

1. Department of Pharmaceutical Sciences, School of Pharmacy University of Pittsburgh Pittsburgh PA USA

2. Department of Pharmacy Fujian Medical University Union Hospital Fuzhou Fujian China

3. College of Arts and Sciences University of Virginia Charlottesville Virginia USA

4. Thomas Starzl Transplantation Institute, School of Medicine University of Pittsburgh Pittsburgh PA USA

5. Department of Pathology, School of Medicine University of Pittsburgh Pittsburgh PA USA

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1111/bcp.14966

Reference33 articles.

1. ZareP HellerD.Treprostinil. StatPearls.2019.

2. A Comprehensive Review of Treprostinil Pharmacokinetics via Four Routes of Administration

3. An evaluation of the pharmacokinetics of treprostinil diolamine in subjects with hepatic impairment

4. https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203496Orig1s000ClinPharmR.pdf. Accessed March 22 2013.

5. PBPK modeling and simulation in drug research and development

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