OCTET-CY: a phase II study to investigate the efficacy of post-transplant cyclophosphamide as sole graft-versus-host prophylaxis after allogeneic peripheral blood stem cell transplantation

Author:

Holtick Udo12,Chemnitz Jens-Markus1,Shimabukuro-Vornhagen Alexander12,Theurich Sebastian12,Chakupurakal Geothy12,Krause Anke1,Fiedler Anne2,Luznik Leo3,Hellmich Martin4,Wolf Dominik5,Hallek Michael1,von Bergwelt-Baildon Michael12,Scheid Christof1

Affiliation:

1. Stem Cell Transplantation Program; Department I of Internal Medicine; Center for Integrated Oncology CIO KölnBonn; University Hospital of Cologne; Cologne Germany

2. Cologne Interventional Immunology; Department I of Internal Medicine; University Hospital of Cologne; Cologne Germany

3. Sidney Kimmel Comprehensive Cancer Center and Department of Oncology; Johns Hopkins University School of Medicine; Baltimore MD USA

4. Institute of Medical Statistics, Informatics and Epidemiology; University of Cologne; Cologne Germany

5. Medical Clinic III for Oncology, Haematology and Rheumatology; Center for Integrated Oncology CIO KölnBonn; University Hospital Bonn; Bonn Germany

Funder

Bundesministerium für Bildung und Forschung

Clinical Trials Center Cologne

Forschungspool Klinische Studien', Faculty of Medicine, University of Cologne

ZKS Köln

Publisher

Wiley

Subject

Hematology,General Medicine

Reference43 articles.

1. Graft-versus-host disease;Ferrara;Lancet,2009

2. Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia;Storb;N Engl J Med,1986

3. Phase 3 study comparing methotrexate and tacrolimus with methotrexate and cyclosporine for prophylaxis of acute graft-versus-host disease after marrow transplantation from unrelated donors;Nash;Blood,2000

4. Phase III study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantation;Ratanatharathorn;Blood,1998

5. A prospective randomized trial comparing cyclosporine and short course methotrexate with cyclosporine and mycophenolate mofetil for GVHD prophylaxis in myeloablative allogeneic bone marrow transplantation;Bolwell;Bone Marrow Transplant,2004

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