In vitro effect of hyoscine‐N‐butyl bromide and diclofenac sodium in human tuba uterina

Author:

Sengul Mustafa1ORCID,Karadas Baris2,Acar‐Sahan Selin2,Ozturk Ozan2,Yılmaz Huseyin2,Simsek Fatma3,Kaya‐Temiz Tijen2

Affiliation:

1. Department of Obstetrics and Gynecology Izmir Katip Celebi University Faculty of Medicine Izmir Turkey

2. Department of Pharmacology Izmir Katip Celebi University Faculty of Medicine Izmir Turkey

3. Department of Histology and Embryology Izmir Katip Celebi University Faculty of Medicine Izmir Turkey

Abstract

AbstractIntroductionTo investigate the in vitro effect of diclofenac on tubal smooth muscle as an alternative to hyoscine‐N‐butyl bromide, which is used for premedication before hysterosalpingography (HSG).Material and MethodsFallopian tubes were retrieved from seven healthy women after bilateral tubal ligation and in vitro contractility and histological studies were conducted using tissue bath and immunohistochemistry.ResultsDiclofenac sodium and hyoscine‐N‐butyl bromide did not significantly change the basal mean tension; however, they decreased the contractions induced by potassium chloride (KCl). The relaxant effect of diclofenac sodium and hyoscine‐N‐butyl bromide was not statistically significantly different. The presence of cyclooxygenase (COX)‐2 enzyme in the fallopian tube was demonstrated by immunohistochemical studies.ConclusionsThe in vitro relaxant effect of diclofenac sodium on the fallopian tube is similar to hyoscine‐N‐butyl bromide. Diclofenac may have the potential to be used as an alternative to hyoscine‐N‐butyl bromide in premedication in HSG.

Publisher

Wiley

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