Chronic Alcohol Exposure and the CircadianClockMutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon

Author:

Summa Keith C.1,Jiang Peng1,Fitzpatrick Karrie1,Voigt Robin M.2,Bowers Samuel J.1,Forsyth Christopher B.23,Vitaterna Martha H.1,Keshavarzian Ali23456,Turek Fred W.1

Affiliation:

1. Center for Sleep & Circadian Biology; Department of Neurobiology; Northwestern University; Evanston Illinois

2. Division of Digestive Diseases and Nutrition; Department of Internal Medicine; Rush University Medical Center; Chicago Illinois

3. Department of Biochemistry; Rush University Medical Center; Chicago Illinois

4. Department of Pharmacology; Rush University Medical Center; Chicago Illinois

5. Department of Molecular Biophysics and Physiology; Rush University Medical Center; Chicago Illinois

6. Division of Pharmacology; Faculty of Science; Utrecht Institute for Pharmaceutical Science; Utrecht University; Utrecht the Netherlands

Funder

National Institutes of Health

National Center for Research Resources (NCRR)

National Center for Advancing Translational Sciences (NCATS)

National Institutes of Health through a Northwestern University Clinical and Translational Sciences Institute Predoctoral Training Grant

National Institutes of Health Training Grant

Publisher

Wiley

Subject

Psychiatry and Mental health,Toxicology,Medicine (miscellaneous)

Reference37 articles.

1. IL-1beta causes an increase in intestinal epithelial tight junction permeability;Al-Sadi;J Immunol,2007

2. Circadian clock regulates the host response to Salmonella;Bellet;Proc Natl Acad Sci USA,2013

3. Circadian and acamprosate modulation of elevated ethanol drinking in mPer2 clock gene mutant mice;Brager;Chronobiol Int,2011a

4. Chronic ethanol disrupts circadian photic entrainment and daily locomotor activity in the mouse;Brager;Alcohol Clin Exp Res,2010

5. Acute ethanol disrupts photic and serotonergic circadian clock phase-resetting in the mouse;Brager;Alcohol Clin Exp Res,2011b

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