Helicobacter pylori infection and risk of cardiovascular disease

Author:

Sun Lichang1,Zheng Haoxiao1,Qiu Min1,Hao Shali1,Liu Xiong1,Zhu Xiaolin1,Cai Xiaoyan2,Huang Yuli13ORCID

Affiliation:

1. Department of Cardiology, Shunde Hospital Southern Medical University Foshan China

2. Department of Scientific Research and Education, Shunde Hospital Southern Medical University Foshan China

3. The George Institute for Global Health, Faculty of Medicine University of New South Wales Sydney New South Wales Australia

Abstract

AbstractBackgroundWhether Helicobacter pylori (H. pylori) infection is associated with an increased risk of cardiovascular disease (CVD) remains controversial. This study aimed to investigate the association between H. pylori infection and the risk of CVD.MethodsPotentially related studies were searched in the electronic databases, including PubMed, EMBASE and Cochrane Library, from inception to 31 August 2022. Observational cohort studies that reported the multivariable‐adjusted relative risks (RRs) for composite CVD, CHD, stroke, or all‐cause mortality associated with H. pylori infection were included in the meta‐analysis, using random‐effects models.ResultsForty‐one cohort studies with 230,288 participants were included. After a median follow‐up duration of 6.3 years, H. pylori infection was associated with a mildly increased risk of composite CVD (RR 1.10, 95% CI 1.03, 1.18) and coronary heart disease (RR 1.10, 95% CI 1.02, 1.18) compared with those without H. pylori infection. No significant association was observed between H. pylori infection and risk of stroke (RR 1.08, 95% CI 0.94, 1.23) or all‐cause mortality (RR 1.02, 95% CI 0.90, 1.16). Compared with cytotoxin‐associated gene‐A (CagA) negative H. pylori infection, the risk of CVD was significantly increased in patients with CagA positive H. pylori infection (RR 1.58, 95% CI 1.03, 2.41).ConclusionsHelicobacter pylori infection is associated with a mildly increased risk of CVD. It may be of great public health and clinical significance to screen H. pylori infection in patients with a high risk of CVD.

Publisher

Wiley

Subject

Infectious Diseases,Gastroenterology,General Medicine

Cited by 18 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3