Prevalence and clinical manifestations of cutaneous findings in patients with adult‐onset immunodeficiency due to anti‐interferon gamma autoantibodies: an eight‐year retrospective study

Abstract

AbstractBackgroundCutaneous findings in adult‐onset immunodeficiency due to anti‐interferon gamma autoantibodies (anti‐IFN‐γ autoAbs) are common. Currently, data on this topic are scarce.MethodsWe retrospectively reviewed medical records of 202 skin episodes from 77 patients diagnosed with adult‐onset immunodeficiency due to anti‐IFN‐γ autoAbs. The exclusion of drug eruptions left 180 episodes from 74 patients for further analysis.ResultsReactive dermatosis was diagnosed in 66.1%, followed by disseminated skin infection (18.3%) and local skin infection (15.6%). Neutrophilic dermatosis (ND) tended to appear on the upper part of bodies, while leg lesions were common in the non‐ND. Disseminated infection occurred more frequently with ND. Mycobacterium abscessus was the most common pathogen of concomitant infection. Remission was achieved in 21.6% and was significantly associated with females.ConclusionReactive dermatosis was the most common skin manifestation. ND was found in the upper part of bodies and associated with disseminated infection. Drug‐free remission was scarcely achieved.